Technology

Anaerobic Storage

zoom-3109765-3Hemanext is developing a technology to enable the storage of RBC under anaerobic conditions. Removing O2 during storage removes the primary “fuel” for oxidative stress1-11. Previous published research has demonstrated that preventing oxidative damage can alleviate many of the signs associated with storage lesion development, including:

Anaerobic storage has been shown to:

Hemanexts continues to invest significant resources in developing the technology and demonstrating both its effect on the characteristics of RBCs during storage, and eventually in clinical usage with patients.

To learn more about the storage lesions and its clinical consequences, click here.

References:
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2. Wolfe LC. Oxidative injuries to the red cell membrane during conventional blood preservation. Seminars in hematology 1989;26:307-12.
3. Tsantes AE, Bonovas S, Travlou A, Sitaras NM. Redox imbalance, macrocytosis, and RBC homeostasis. Antioxidants & redox signaling 2006;8:1205-16.
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8. Jarolim P, Lahav M, Liu SC, Palek J. Effect of hemoglobin oxidation products on the stability of red cell membrane skeletons and the associations of skeletal proteins: correlation with a release of hemin. Blood 1990;76:2125-31.
9. Shalev O, Hebbel RP. Extremely high avidity association of Fe(III) with the sickle red cell membrane. Blood 1996;88:349-52.
10.Zinkham WH, Houtchens RA, Caughey WS. Carboxyhemoglobin levels in an unstable hemoglobin disorder (Hb Zurich): effect on phenotypic expression. Science 1980;209:406-8.
11.Wolfe LC, Byrne AM, Lux SE. Molecular defect in the membrane skeleton of blood bank-stored red cells. Abnormal spectrin-protein 4.1-actin complex formation. The Journal of clinical investigation 1986;78:1681-6.